MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù),。

Phorbol 12-myristate 13-acetate

CAS No. : 16561-29-8

MCE 國際站：Phorbol 12-myristate 13-acetate

產(chǎn)品活性：Phorbol 12-myristate 13-acetate (PMA) 是一種佛波酯,，是蛋白激酶 C (PKC) 和 SphK 的激活劑。Phorbol 12-myristate 13-acetate 是 NF-κB 激活劑,。Phorbol 12-myristate 13-acetate 可誘導(dǎo) THP-1 細(xì)胞分化 (已經(jīng)經(jīng)過 MCE 專業(yè)的生物實(shí)驗(yàn)驗(yàn)證),。

研究領(lǐng)域：Epigenetics  |  TGF-beta/Smad  |  Immunology/Inflammation  |  NF-κB

作用靶點(diǎn)：PKC  |  SphK  |  NF-κB

In Vitro: PMA (100, 200 ng/mL; 1-5 days) induce THP-1 cells to differentiate into macrophage-like cells (THP-1 macrophages), characterized by changes in morphology (adherent macrophage-like phenotype), and increases cell surface expression of CD11b.
PMA (20 ng/mL, 36 h) inhibits endothelial cell migration through activating the PKC-δ/Syk/NF-κB-mediated up-regulation of Thy-1.

In Vivo: Phorbol 12-myristate 13-acetate (PMA) can be used to create models of ear edema and paw edema.

相關(guān)產(chǎn)品：Natural Product Library Plus  |  Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Immunology/Inflammation Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  TGF-beta/Smad Compound Library  |  Natural Product Library  |  Clinical Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Antioxidant Compound Library  |  Lipid Compound Library  |  Oxygen Sensing Compound Library  |  Pyroptosis Compound Library  |  Cytoskeleton Compound Library  |  Traditional Chinese Medicine Active Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Transcription Factor-Targeted Library  |  Animal Disease Model Inducer Library  |  Anti-inflammatory Traditional Chinese Medicine Active Compound Library  |  Plant-Sourced Natural Product Library  |  Human Metabolite Library  |  Coagulation and Anti-coagulation Compound Library  |  Pain-Related Compound Library  |  Membrane Protein-targeted Compound Library  |  Multi-Target Compound Library  |  Radioprotector Library  |  Bioactive Compound Library Max  |  Protein Kinase Compound Library  |  Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library  |  Cell Proliferation Compound Library  |  Forskolin  |  Staurosporine  |  Bortezomib  |  BAY 11-7082  |  Ionomycin  |  TAK-243  |  JSH-23  |  Shikonin  |  Go 6983  |  Aspirin  |  Triptolide  |  Sulfasalazine  |  Baicalin  |  Uridine  |  5-Aminosalicylic Acid  |  Mitoxantrone  |  Dihydroartemisinin  |  Pyrrolidinedithiocarbamate ammonium  |  Hyaluronidase, Bovine testes  |  Midostaurin  |  Ergothioneine  |  Fasudil Hydrochloride  |  GYY4137  |  Parthenolide  |  Human serum albumin  |  Isoginkgetin  |  Bisindolylmaleimide I  |  Astaxanthin  |  Andrographolide

熱門產(chǎn)品線：重組蛋白  |  藥物篩選  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標(biāo)記物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds

品牌介紹:
?   MCE (MedChemExpress) 擁有200 多種全球獨(dú)家化合物庫，我們致力于為全球科研客戶提供前沿最全的高品質(zhì)小分子活性化合物,；
?   50,000 多種高選擇性抑制劑,、激動劑涉及各熱門信號通路及疾病領(lǐng)域；
?   產(chǎn)品種類涵蓋各種重組蛋白，多肽,，常用試劑盒 ,，更有 PROTAC、ADC 等特色產(chǎn)品,，廣泛應(yīng)用于新藥研發(fā),、生命科學(xué)等科研項(xiàng)目；
?   提供虛擬篩選,，離子通道篩選,，代謝組學(xué)分析檢測分析，藥物篩選等專業(yè)技術(shù)服務(wù),；
?   設(shè)有專業(yè)的實(shí)驗(yàn)中心和嚴(yán)格的質(zhì)控,、驗(yàn)證體系；
?   提供 LC/MS,、NMR,、HPLC、手性分析,、元素分析等各項(xiàng)質(zhì)檢報告,，確保產(chǎn)品的高純度、高品質(zhì),；
?   產(chǎn)品的生物活性多經(jīng)各國客戶實(shí)驗(yàn)驗(yàn)證,；
?   Nature, Cell, Science 等多種頂級期刊及制藥專利收錄了MCE客戶的科研成果；
?   專業(yè)團(tuán)隊(duì)跟蹤最新的制藥及生命科學(xué)研究進(jìn)展,，為您提供全球最新的活性化合物,；
?   與世界各大制藥公司及知名科研機(jī)構(gòu)建立了長期的合作。