喀斯瑪商城-第三方B2B電子商務(wù)平臺

MIST1/bHLHa15 (D7N4B) XP Rabbit mAb

商城價(jià)：登錄可見

品牌：CST/賽信通

貨號：14896T

規(guī) 格：

運(yùn)費(fèi)：登錄后可查看運(yùn)費(fèi)

DeepBio得分:

DeepBio得分是基于文獻(xiàn)引用次數(shù)，影響因子，文獻(xiàn)新近度等因素計(jì)算的客觀產(chǎn)品評級，得分越高表明該產(chǎn)品經(jīng)過越可靠的實(shí)驗(yàn)驗(yàn)證，質(zhì)量可信度越高

2家供應(yīng)商在售
商品名稱	規(guī)格	代理級別	價(jià)格	運(yùn)費(fèi)	供應(yīng)商	購買
MIST1/bHLHa15 (D7N4B) XP ? Rabbit mAb 交貨周期:現(xiàn)貨	20 μl	經(jīng)銷	登錄可見	-	北京敏泰元科技有限公司	- + 立即購買庫存：20
CST 14896T MIST1/bHLHa15(D7N4B)XP Rabbit mAb 交貨周期:部分現(xiàn)貨，期貨3-4周左右，優(yōu)質(zhì)售后	20μl	經(jīng)銷	登錄可見	-	上海優(yōu)寧維生物科技股份有限公司	- + 立即購買庫存：999

產(chǎn)品詳情

文獻(xiàn)引用

文獻(xiàn)圖片

實(shí)驗(yàn)數(shù)據(jù)

應(yīng)用：W, IHC-P
反應(yīng)性:R
Class A basic helix-loop-helix protein 15 (MIST1, bHLHa15) is a highly conserved basic helix loop helix family transcription factor that binds E-box motifs and regulates the expression of developmentally regulated genes (1).MIST1 can bind DNA as a homodimer, or may heterodimerize with other bHLH proteins to regulate target gene expression (1).MIST1 is expressed in an array of tissues, including salivary glands, stomach, small intestine, and the pancreas, but is generally restricted to secretory cell subtypes (2). In the pancreas, MIST1 is essential for the maturation, maintenance, and function of acinar cells (3). In gastric chief cells, MIST1 regulates the expression of RAB26 and RAB3D, two GTPases that function to regulate secretory granule formation (4). Loss of MIST1 in gastric chief cells may be a potential marker of gastric epithelial neoplasia (5).

Supporting Data

REACTIVITY	H M
SENSITIVITY	Endogenous
MW (kDa)	23
Source/Isotype	Rabbit IgG

Application Key:

W-Western
IP-Immunoprecipitation
IHC-Immunohistochemistry
ChIP-Chromatin Immunoprecipitation
IF-Immunofluorescence
F-Flow Cytometry
E-P-ELISA-Peptide

Species Cross-Reactivity Key:

H-Human
M-Mouse
R-Rat
Hm-Hamster
Mk-Monkey
Vir-Virus
Mi-Mink
C-Chicken
Dm-D. melanogaster
X-Xenopus
Z-Zebrafish
B-Bovine
Dg-Dog
Pg-Pig
Sc-S. cerevisiae
Ce-C. elegans
Hr-Horse
All-All Species Expected

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunohistochemistry (Paraffin)	1:100

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

MIST1/bHLHa15 (D7N4B) XP^?Rabbit mAb recognizes endogenous levels of total MIST1/bHLHa15 protein.

Species Reactivity:

Human, Mouse

Species predicted to react based on 100% sequence homology:

Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln181 of human MIST1/bHLHa15 protein.

Background

Class A basic helix-loop-helix protein 15 (MIST1, bHLHa15) is a highly conserved basic helix loop helix family transcription factor that binds E-box motifs and regulates the expression of developmentally regulated genes (1). MIST1 can bind DNA as a homodimer, or may heterodimerize with other bHLH proteins to regulate target gene expression (1). MIST1 is expressed in an array of tissues, including salivary glands, stomach, small intestine, and the pancreas, but is generally restricted to secretory cell subtypes (2). In the pancreas, MIST1 is essential for the maturation, maintenance, and function of acinar cells (3). In gastric chief cells, MIST1 regulates the expression of RAB26 and RAB3D, two GTPases that function to regulate secretory granule formation (4). Loss of MIST1 in gastric chief cells may be a potential marker of gastric epithelial neoplasia (5).

Lemercier, C. et al. (1997) Dev Biol 182, 101-13.
Pin, C.L. et al. (2000) Anat Rec 259, 157-67.
Pin, C.L. et al. (2001) J Cell Biol 155, 519-30.
Tian, X. et al. (2010) Mol Cell Biol 30, 1269-84.
Lennerz, J.K. et al. (2010) Am J Pathol 177, 1514-33.