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CD5 (E8X3S) XP Rabbit mAb

商城價：登錄可見

品牌：CST/賽信通

貨號：39300T

規(guī) 格：

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DeepBio得分:

DeepBio得分是基于文獻引用次數(shù)，影響因子，文獻新近度等因素計算的客觀產(chǎn)品評級，得分越高表明該產(chǎn)品經(jīng)過越可靠的實驗驗證，質(zhì)量可信度越高

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商品名稱	規(guī)格	代理級別	價格	運費	供應商	購買
CD5 (E8X3S) XP ? Rabbit mAb 交貨周期:現(xiàn)貨	20 μl	經(jīng)銷	登錄可見	-	北京敏泰元科技有限公司	- + 立即購買庫存：20
CST 39300T CD5(E8X3S)XP Rabbit mAb 交貨周期:部分現(xiàn)貨，期貨3-4周左右，優(yōu)質(zhì)售后	20μl	經(jīng)銷	登錄可見	-	上海優(yōu)寧維生物科技股份有限公司	- + 立即購買庫存：999

產(chǎn)品詳情

文獻引用

文獻圖片

實驗數(shù)據(jù)

應用：W, IP, IHC-Bond, IHC-P
CD5 is a type-I transmembrane protein belonging to the scavenger receptor cysteine-rich (SRCR) family, characterized by the presence of at least one SRCR domain of 90-110 amino acids. CD5 is expressed by all mature T cells, the B-1a subset of mature B cells, and some leukemic B cells. Its expression is increased in regulatory T and B cells (Tregs/Bregs). Anergic T and B cells also have elevated CD5 expression. Elevated levels of CD5 are also found in many autoimmune disorders (1-3). CD5 is associated with the T cell receptor (TCR) and negatively modulates T cell activation and differentiation. CD5 expression on the tumor infiltrating T lymphocytes is inversely correlated with their antitumor activity (4-6). Recently it was reported that CD5 directly binds to IL6 and can mediate downstream signaling. CD5+ B cells promote tumor growth in animal models (7). Reagents targeting CD5 have been actively pursued as therapeutic interventions for cancer and other conditions (8,9).

Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	65
Source/Isotype	Rabbit IgG

Application Key:

W-Western
IP-Immunoprecipitation
IHC-Immunohistochemistry
ChIP-Chromatin Immunoprecipitation
IF-Immunofluorescence
F-Flow Cytometry
E-P-ELISA-Peptide

Species Cross-Reactivity Key:

H-Human
M-Mouse
R-Rat
Hm-Hamster
Mk-Monkey
Vir-Virus
Mi-Mink
C-Chicken
Dm-D. melanogaster
X-Xenopus
Z-Zebrafish
B-Bovine
Dg-Dog
Pg-Pig
Sc-S. cerevisiae
Ce-C. elegans
Hr-Horse
All-All Species Expected

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:200
IHC-Leica? Bond?	1:400
Immunohistochemistry (Paraffin)	1:800

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

CD5 (E8X3S) XP^? Rabbit mAb recognizes endogenous levels of total CD5 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly219 of human CD5 protein.

Background

CD5 is a type-I transmembrane protein belonging to the scavenger receptor cysteine-rich (SRCR) family, characterized by the presence of at least one SRCR domain of 90-110 amino acids. CD5 is expressed by all mature T cells, the B-1a subset of mature B cells, and some leukemic B cells. Its expression is increased in regulatory T and B cells (Tregs/Bregs). Anergic T and B cells also have elevated CD5 expression. Elevated levels of CD5 are also found in many autoimmune disorders (1-3). CD5 is associated with the T cell receptor (TCR) and negatively modulates T cell activation and differentiation. CD5 expression on the tumor infiltrating T lymphocytes is inversely correlated with their antitumor activity (4-6). Recently it was reported that CD5 directly binds to IL6 and can mediate downstream signaling. CD5+ B cells promote tumor growth in animal models (7). Reagents targeting CD5 have been actively pursued as therapeutic interventions for cancer and other conditions (8,9).

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Soldevila, G. et al. (2011) Curr Opin Immunol 23, 310-8.
Sigal, L.H. (2012) J Clin Rheumatol 18, 83-8.
Azzam, H.S. et al. (2001) J Immunol 166, 5464-72.
Dalloul, A. (2009) Autoimmun Rev 8, 349-53.
Henderson, J.G. et al. (2015) Immunity 42, 471-83.
Zhang, C. et al. (2016) Immunity 44, 913-923.
Consuegra-Fernández, M. et al. (2015) Crit Rev Immunol 35, 85-115.
Consuegra-Fernández, M. et al. (2015) Crit Rev Immunol 35, 85-115.